EXPLORE!

CNS Update: Difference in the regulation of biological rhythm symptoms of MDD between escitalopram and mirtazapine

  1215 Views

eMediNexus    24 February 2023

Biological rhythm has a key role in major depressive disorder (MDD) but the efficacy of antidepressants in Biological rhythm is less explored. 

 

Thus a study explored the efficiency of escitalopram and mirtazapine in refining circadian rhythm, diurnal mood variation (DMV) and daily activity in patients with MDD.

 

450 participants diagnosed with MDD received treatment with escitalopram (TWE), treatment with mirtazapine (TWM) or treatment as usual (TAU).  The Hamilton depression scale (HAMD) and the quick inventory of depressive symptomatology self-report (QIDS) assessed the Biological rhythm symptoms at baseline, weeks 2, 4, 6 and 8.

 

All treatment groups showed significant differences in HAMD scores, but these were significant only in patients without DMV. TWM showed marked improvement in Sleep rhythm items (difficulty falling asleep and early-wake), decreased appetite and weight on both HAMD and QIDS scales. TWE demonstrated marked improvement relating to daily activity-related items, feeling slowed down and concentration. TWE and TWM both significantly improved retardation.

 

Thus escitalopram, as well as mirtazapine, proved their superior anti-depressive effect, particularly for MDD patients without DMV. Escitalopram displayed higher effectivity relating to daily activity, feeling slowed down and concentration difficulty.

 

Journal of Affective Disorders, 2022;296(1):258-264. https://www.sciencedirect.com/science/article/abs/pii/S0165032721010090

To comment on this article,
create a free account.

Sign Up to instantly get access to 10000+ Articles & 1000+ Cases

Already registered?

Login Now

Most Popular Articles

News and Updates

eMediNexus provides latest updates on medical news, medical case studies from India. In-depth medical case studies and research designed for doctors and healthcare professionals.